Barely Significant
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Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort.

Transl Psychiatry · 2020 · PMC7176736 · PMID 32321915

Europe PMCDOI
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closest p · 1.0× alpha
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The sentences

nominally significantP < 0.05actually significant
Interestingly, the two nominally significant CpG sites ( P < 0.05) that overlap between the cannabis-only and the cannabis with tobacco data are located within the MARC2 and CUX1 genes, which both have reported roles in brain function; a SNP in MARC2 has been provisionally associated with the biological response to antipsychotic therapy in schizophrenia patients 77 , and the CUX1 gene has an established role in neural development 78 .

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