Among treated patients with an INR < 1.2 in that trial, there was a strong trend towards improved survival although the increased bleeding risk persisted.
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The sentences
In a randomized, double blinded, placebo controlled, multicenter trial of 1,690 adults with severe sepsis and at least one sepsis-induced organ dysfunction, the infusion of a recombinant form of human activated protein C (drotrecogin alfa) resulted in a highly significant reduction in 28-day all cause mortality.