A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India.

Indian J Anaesth · 2020 · PMC7179772 · PMID 32346163

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an increasing trendno p-value reported

More recent studies with similar severity indices have shown an increasing trend in mortality.[ 8 , 9 ] A study in Taiwan published in 2016 with 143 critically ill patients and mean APACHE Score of 17.9 reported a mortality of 23.1%.

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failed to reach statistical significanceno p-value reported

Raised ALT levels has been shown to be associated with worse outcomes in several studies.[ 19 ] However, in our study Bilirubin (>2.0 mg/dl) was associated with the risk of mortality in the multivariate analysis, but elevated ALT (>3 × ULN) failed to reach statistical significance suggesting that both hepatocyte necrosis as well as biliary obstruction due to oedema contribute to hepatic dysfunction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.