Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population.

In the ADH cluster locus, we also observed nominally significant positive selection pressure at the well-known functional missense variant of ADH1B , which is associated with lower alcohol consumption, as well (rs1229984-A [Arg48His], P iHS = 7.1 × 10 −4 with iHS z -score = 3.39, r 2 = 0.34 with rs1442493 in Japanese; fig. 2 b ; Koganebuchi et al. 2017 ; Okada 2018 ).

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