Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion.

Finally, in islets from donors with type 2 diabetes we find similarly that acute exposure to Exendin 4 has no effect on insulin content (Figure 1g ) and modestly increases insulin secretion at 10 mM glucose, although this did not reach statistical significance (Figure 1h ). 3.2.

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