Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules.

Moreover, we found that treatment of CBMC with IL-12 combined with anti-CD28 and anti-CD137 co-stimulation also had no impact on the cytolytic activity of T cells from CBMC when used with HIV × CD3 DART molecules, but did increase activity in assays performed with adult PBMC ( Figure 3C ), although the increase did not reach statistical significance ( p = 0.064, Wilcoxon rank sum test).

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