MC1R variants and associations with pigmentation characteristics and genetic ancestry in a Hispanic, predominately Puerto Rican, population.

We noted a significant trend (p = 0.0004) across MC1R risk categories with tendency to burn: Hispanic individuals in the medium (OR: 3.4, 95% CI: 1.2–9.2; p = 0.017) and high (OR: 8.4, 95% CI: 2.5–28; p = 0.0005) MC1R risk categories were more likely to report skin that burned (including sunburn without blistering and severe burning with blistering) compared to those in the low MC1R risk category.

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