Interplay of <i>PNPLA3</i> and <i>HSD17B13</i> Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients.

Running two further conditional logistic regression models (i.e., substituting the dummy variable “high-risk genetic combination” either with each variant of the genes of interest, or with an interaction term) demonstrated only a nonsignificant trend ( p = 0.061) for the stratum of patients corresponding to carriers of the “high-risk combination”, but the likelihood ratio test did not detect any significant difference between the two models ( p = 0.355). 4.

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Moreover, the fact that the association between the two genes of interest and HCC did not reach statistical significance when all their combinations were tested together suggests that our findings await confirmation in larger studies on prospectively recruited patients.

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