The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.

However, the OS differences between patients harbouring these alterations did not reach statistical significance ( P = 0.5), likely due to the small size of the cohort. p140Cap negatively affects tumorigenic features The above data provided us with the testable hypothesis that the expression of the SRCIN1 gene product, the p140Cap adaptor protein, may attenuate the intrinsic biological aggressiveness of NB tumors.

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The multivariate Cox analysis including other known risk factors ( MYCN amplification, INSS stage, and age at diagnosis) showed that SRCIN1 expression was an independent favorable prognostic factor, both in terms of OS and EFS, with low Hazard Ratio (HR) and highly significant P -value (Fig. 1c ).

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