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Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.

BMJ Open Diabetes Res Care · 2020 · PMC7206972 · PMID 32098895

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Interestingly, the treatment with ex vivo expanded Tregs in patients with LDT1DM was associated with the most significant reduction in the level of Tn Tregs, while changes in memory compartments did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.