Importantly, deletion of either SWE1 or HOG1 largely prevented downregulation of the G2/M genes CLB2 , CDC5 and CDC20 , and swe1Δ hog1Δ cells showed a slightly stronger effect on the same targets, although this difference did not reach statistical significance for all comparisons ( Fig 7E ).
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The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.
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