A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.

Heterogeneity tests were also highly significant ( p FDR = 4.78 × 10 −7 for Q test and 3.33 × 10 −4 for MR-Presso global test).

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Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

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