Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort.

We found that elevated soluble IL-17A was correlated with increased intratumoral presence of CD8 + TIM3 + cells (r=0.623, p=0.042, online supplementary figure S5 ) and that circulating neutrophils were inversely correlated with intratumoral T-cell density as quantified by TCR sequencing, although the latter association did not reach statistical significance (r=−0.265, p=0.086, online supplementary figure S6 ).

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