The exacerbation rate during eculizumab treatment in REGAIN and the OLE was reduced considerably from that in the year before REGAIN start and from that in the REGAIN placebo group, yet these differences did not reach statistical significance, probably owing to inadequate power with the small sample size.
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Response to eculizumab in patients with myasthenia gravis recently treated with chronic IVIg: a subgroup analysis of REGAIN and its open-label extension study.
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