Prostaglandin E₂ in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8⁺ T cells.

The phenotype of the whole expanded T-cell pool on day 10 showed a trend for more effector T-cells with the TLR-matured DCs: starting from a homogenous naïve T-cell population, CD62L and CD45RA were subsequently downregulated and most T-cells were in naïve-memory transition after 10 days of expansion under these conditions (Fig. 3 d).

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