Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice.

A borderline significant decrease in bodyweight of the KO mice with a concomitant significant reduction in diastolic circumference, assessed by ultrasound ( Table S1 ), was detected.

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In contrast, increased flow did not affect the elastic laminae content in PCSK6 deficient mice, but comparison between WT and KO mice exposed to increased flow revealed a borderline significant trend ( Figure 4 C,D).

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