Serum levels of BMP4 were also higher in women with preeclampsia than in controls, but this trend did not reach statistical significance ( Figure 3 B; 23.66 [range 14.26–36.27] versus 16.78 [range 2.67–43.54], respectively, p = 0.13).
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Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4.
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The expression of BMP4 was clearly upregulated in the lung (~1.8-fold induction), duodenum (~2.5-fold induction), and stomach (~2.5-fold induction) of sEng + compared to WT mice and these differences were highly significant.