Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy.

24 It should be noted that, as seen in Figure 2 , AT1R expression increased significantly only in class IIb DN patients; AT2 and MAS have an increasing trend, and there were no significant change in angiotensin II receptor expression in class I+IIa and class III+IV.

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4 In another study, AT1 mRNA expression of non-diabetic subjects tended to be higher than that of diabetic subjects, but this difference did not reach statistical significance, and the AT2 mRNA expression level of diabetic subjects was comparable to that of non-diabetic subjects. 5 Only one study used a semiquantitative histochemical method to assay AT1 protein expression, and this study found AT1R expression was lower than AT2R expression in the 10 samples from patients with DN. 22 Our study is the first to assess angiotensin receptors (AT1, AT2, and MAS) protein expression in a large sample of human patients with DN.

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