Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.

Indeed, although CX3CL1 −/− animals showed a slight trend towards increased motor learning, this difference did not reach significance when compared to the other treatment groups.

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Mice that were treated with either mFKN or sFKN showed a trend towards increased exploration of the target zone, similar to WT mice, and showed significantly less exploration in the − 1 (mFKN and sFKN) and + 1 (mFKN) zones than mice receiving GFP (Fig. 3 b, c).

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