One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.

Consistent with our hypothesis, the reduced mitochondrial and fat oxidative capacity in muscle of the inactive leg was accompanied by higher [ 14 C]palmitate incorporation into TAGs, suggesting that a low oxidative capacity accelerates IMCL accumulation, although this measure did not reach statistical significance probably due to the low number of participants in our study.

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