Randomised trials and meta-analyses of double vs triple antithrombotic therapy for atrial fibrillation-ACS/PCI: A critical appraisal.

Indeed, in one of the most recent analyses [13] , the odds of ST with DAT vs TAT increased 60%, with a number needed to treat (NNT) for a harmful outcome (NNTH) of 274 and an associated borderline significant increase of MI (NNTH = 151) ( Fig. 2 and Fig. 3 ).

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The authors acknowledge ‘a very early numerical increase in ischaemic events in patients without aspirin’, with a nonsignificant trend toward increased risk of MI (HR 1.26, 95% CI 0.72–2.16) and ST (HR 1.32, 0.46–3.79), although the trial was not powered to assess efficacy outcomes ( Table 1 ).

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Unlike DAT with dabigatran 150 mg bid, DAT with dabigatran 110 mg bid showed a trend towards increased rates of MI and ST compared to TAT [1] .

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