<i>N</i>-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.

RA-differentiated SH-SY5Y exposed to HMB-isatin displayed modestly reduced conductance (G max : 55.26 ± 9.3 nS, p = 0.5562) and current density (92.2 ± 6.7 pA/pF, p = 0.0885) in comparison to vehicle treated control cells (61.30 ± 5.4 nS, 111.7 ± 8.0 pA/pF, respectively), however these changes did not reach statistical significance (Fig. 6 c, Additional file 1 : Table S2).

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