Novel <i>SCN9A</i> missense mutations contribute to congenital insensitivity to pain: Unexpected correlation between electrophysiological characterization and clinical phenotype.

Analysis of the steady-state fast inactivation properties showed that p.Arg99His channels exhibited a slight hyperpolarizing shift by −2 mV (−83.98 ±1.82 mV for WT and −85.43 ± 1.59 mV for p.Arg99His), which did not reach statistical significance ( Figure 2(f) to (h) ).

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