Knock-in rats with homozygous <i>PSEN1<sup>L435F</sup></i> Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43.

J Biol Chem · 2020 · PMC7247318 · PMID 32265300

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3 B ) Interestingly, only one allele with the Psen1 LF mutation was sufficient to drive the increase in Aβ43 levels, whereas the Aβ43/Aβ40 and Aβ43/Aβ42 ratios showed a trend of gene dose dependence and significant gene dose dependence, respectively (Aβ43/Aβ40: F(5,18) = 26.70, p < 0.0001; Aβ43/Aβ42: F(5,18) = 15.15, p < 0.0001).

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