Serum IL-35 Levels Are Associated With Activity and Progression of Sarcoidosis.

Moreover, IL-35 can induce production of Tregs that produce IL-35 (iTr35), and to promote the proliferation of Tregs, and limit the differentiation and functions of Th17, which is highly significant in maintaining Th17/Treg cell balance ( 6 , 23 , 24 ).

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The levels of serum IL-35 were dynamically monitored during the follow-up period, and the findings suggested that patients with progressive disease had a decreasing trend, however the IL-35 levels did not change significantly for patients with improved or stable disease conditions, which indicated that decreased levels of serum IL-35 might predict that the disease was severe, although the specific mechanism remains unclear.

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The lymphocytes in the PA+IL-35Ab group were increased as compared to the PA group, which showed a trend of aggravated inflammation ( Figure 6A ).

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