Glutamine deprivation resulted in a significant upregulation of ROS levels in SH-SY5Y cells, while only a small trend was shown in BE(2)-C cells (Figures 5 H).
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Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation.
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Our results showed a trend towards increased resistance to irradiation upon glutamine deprivation in both the cell lines expressing MycN ( Figures S2 G, H and I, comparison between colour lines).