Barely Significant
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The Nuss procedure for pectus excavatum: An effective and safe approach using bilateral thoracoscopy and a selective approach to use multiple bars in 296 adolescent and adult patients.

PLoS One · 2020 · PMC7259695 · PMID 32470011

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a significant trendno p-value reported
Valvular regurgitation was also observed in older patients, with a significant trend, and might be associated with cardiopulmonary symptoms.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.