In addition to sequence divergence, we also observed a strong trend of replaceable 1:2 human co-orthologs to have broader, less–tissue-specific expression.
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Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs.
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The sentences
We observe a variable pattern of replaceability across different ortholog classes, with an obvious trend toward differential replaceability inside gene families, and rarely observe replaceability by all members of a family.