Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator.

( Figures 7J,K ) Soluble Guanylyl Cyclase Activator Improves Kinases Involved in Hypertrophic Pathways and Reduces Pro-Inflammatory Cytokines and Oxidative Stress in Human Heart Failure With Preserved Ejection Fraction Human HFpEF myocardium biopsies showed a trend similar to that observed in DSS rats, with a significant reduction of the sGC–cGMP–PKG pathway that could be attenuated upon treatment with sGC activator ( Figures 8A–C ).

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