Compared with in vitro reconstructed normal skin, the keloid model showed a trend of increased dermal thickness, increased α-SMA and p16 expression, reduced HGF secretion and reduced collagen type IV α2 chain, hyaluronan synthase 1 and matrix metalloproteinase 3 gene expression.
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The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.
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