Loss of the transcription factor MAFB limits β-cell derivation from human PSCs.

Moreover, SST and PPY were upregulated compared with controls in both MAFB+/− and −/− cells, although PPY did not reach statistical significance (SST+ 1.0 vs. 3.2 ± 2.1 vs. 5.9 ± 1.3; PPY + 1.0 vs. 0.8 ± 0.6 vs. 2.1 ± 1.6) and C-PEP+ GCG+ cell numbers were significantly reduced (1.0 vs. 0.7 ± 0.2 vs. 0.2 ± 0.1).

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