Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.

Leave-one-out Analyses To identify gene-based results driven by one or more variants, we applied the following leave-one-out strategy: 1- among the variants seen more than twice in our stage 1 sample (cases and controls together), we identified the variant with the lowest single-variant analysis p value whenever it is nominally significant (p < 0.05); 2- we removed this variant and performed the stage 1 gene-based test again.

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