Intravitreal safety profiles of sol-gel mesoporous silica microparticles and the degradation product (Si(OH)₄).

The incidence of reaction around the depot was significantly increased in eyes with larger pored particles and there was a significant trend for higher incidence of vitreous reaction with larger pores (10 nm: 0%, 30 nm: 29%, 50 nm: 71%, 100 nm: 100%, p < .0001, Cochran Armitage Trend Test).

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