As for the possible adverse events, resulting from a more intensive pharmacological treatment, if it is true that the cases of hypotension, even severe, falls, electrolyte imbalance, and acute renal failure were higher in patients with lower blood pressure, it is also true that the difference between the various groups did not reach statistical significance. 10 By virtue of these numerous and increasingly convincing observations, both the new guidelines of the American College of Cardiology/American Heart Association (ACC/AHA), published in 2017, 2 and those of the European Society of Cardiology/European Society of Hypertension (ESC/ESH), 1 just published, reviewed the therapeutic goal of blood pressure 140/90 mmHg, identifying the new goal of 130/80 mmHg for all hypertensive patients aged between 18 and 65 years (recommendation in Class IA), or lower if well-tolerated.
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