Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous <i>Lrrk2</i> mutations and ameliorated by <i>Lrrk2</i> genetic knock-out.

On average ∼4% of cells were classified as ACBs in WT PFF-treated neurons and, while there was a strong trend towards a reduced proportion of ACBs in sister cultures from LKO mice, there was no significant difference in the number of ACBs ( Fig. 3D ).

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When analysis of pS129 aSyn signal was conducted in the absence of ACBs (masked out), to give neuritic pS129 aSyn staining, there was still a highly significant decrease in LKO cultures ( Fig. 3F ).

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