Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry.

These comparisons indicated similar effect sizes between symptom categories of guilt, loss of energy, and suicidality while there was a strong divergence between symptom categories of work and interests and loss of libido. As meta-analytic results indicate, few symptoms showed nominally significant differences between psychotherapy and ADM (favouring ADM: HAM-D item 4 [insomnia: early], BDI item 2 [pessimism] and BDI item 13 [indecisiveness]; favouring psychotherapy: BDI item 19 [concentration difficulty]).

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