nominally significantp < 0.05
Even among nominally significant DEGs (nDEGs p < 0.05; cortex n = 1567; striatum n = 906; cerebellum n = 487), there was limited overlap, with significant similarities being seen only among downregulated genes (Fig. 2 c and Supplementary Table 4), indicating that the effects of Mbd5 reduction are largely different across these three brain regions.