Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway.

Biomolecules · 2020 · PMC7277209 · PMID 32466182

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did not reach statistical significanceno p-value reported

The nitrate side-chains did reduce MMP-9 expression when tested at 10 μM ( Figure 2 ), but this inhibition did not reach statistical significance except for compound 3f .

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