Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping.

The highest enriched category for bQTL variants was “Myocardial infarction” and for caQTLs “CARDIoGRAMplusC4D” and “Coronary artery calcification.” clQTL variants were enriched for “Myocardial infarction,” “CardiogramplusC4D,” and the highly significant term “Coronary artery,” which was the second most significant category ( P < 10 −100 ) ranked by P value (Fig. 2 a–c).

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While the bQTLs showed a trend in the correct direction, they did not show a significant correlation (Fig. 2 g).

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