Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington's disease (Enroll-HD).

However, for irritability, while both groups had similar rates of decline during time interval 1, the group starting antidopaminergic medication displayed a strong trend for a reduced rate of increase in post-medication (t (78)=1.872, p = 0.065), which meant that they had a significantly lower average increase than the matched control group during time interval 2 (F (1, 175)=10.061, p = 0.002) (see figure 2C ).

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