Prevention of Early Alzheimer's Disease by Erinacine A-Enriched <i>Hericium erinaceus</i> Mycelia Pilot Double-Blind Placebo-Controlled Study.

Front Aging Neurosci · 2020 · PMC7283924 · PMID 32581767

Europe PMC DOI

hedged sentences

0.0330

closest p · 0.7× alpha

0.0580

boldest claim

The sentences

did not reach statistical significancep = 0.033actually significant

Nevertheless, all these groups did not reach statistical significance except for the changes in CS OU from baseline to 49 weeks in the placebo group (0.85 ± 0.19 to 0.85 ± 0.08; p = 0.033) and differences of CS OS at week 49 between treatment groups ( p = 0.046).

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an increasing trendp = 0.058so close (0.05 < p ≤ 0.1)

marginal significancep = 0.058so close (0.05 < p ≤ 0.1)

a decreasing trendp = 0.064so close (0.05 < p ≤ 0.1)

Moreover, when compared to the baseline values and different time points of CASI scores, subjects in the EAHE group showed an increasing trend with marginal significance (71.75 ± 17.12 to 75.35 ± 15.86; p = 0.058) whereas the subjects in the placebo group showed a decreasing trend from the baseline to 49 weeks (73.52 ± 14.51 to 69.67 ± 16.62; p = 0.064).

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