Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum.

Our data suggested that the best site to monitor might be the neck, due to the following findings: (1) Neck skin took up more 18F-NaF than any vessel wall; (2) the uptake of 18F-NaF in the neck tended to increase as the disease severity increased (this trend probably did not reach statistical significance due to low statistical power); (3) vascular calcification is a very common process, and thus it is not specifically indicative of PXE; (4) 18F-NaF uptake occurs physiologically in the arteries but not in skin [ 26 ]; and (5) at one year, etidronate was shown to reduce ectopic arterial mineralization by 4% in patients with PXE, despite a 6% increase in the TBR at the femoral level, in both treated and control groups [ 11 ].

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