The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3.

African-lineage strains were significantly less sensitive to the effects of IFNα and showed a trend for a difference with IFNβ compared to Asian-lineage strains.

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As an aggregate, African-lineage ZIKV strains were significantly less susceptible to IFNα restriction than Asian-lineage strains ( Figure 2 b; p = 0.049); they were also less susceptible to IFNβ, though differences in sensitivity to IFNβ ( Figure 2 b; p = 0.09) were only a statistical trend.

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