Deficiency of GABARAP but not its Paralogs Causes Enhanced EGF-induced EGFR Degradation.

In fact, GABARAPL1 SKO cells displayed a slight trend towards higher EGFR total protein levels over time, while a slight but significant (1.32-fold, p ≤ 0.05) increase in the basal total EGFR levels was observed for GABARAPL2 SKO cells.

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No significant correlation for GABARAPL1 or GABARAPL2 with EGFR protein levels was found for any of the time points analyzed, although GABARAPL1 showed a trend towards negative correlation with EGFR levels at basal conditions ( r = −0.27) and after 120 min.

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