Skeletal muscle antagonizes antiviral CD8⁺ T cell exhaustion.

Although the MIL-derived progeny cells showed a trend toward lower percentages of CD244 + PD-1 + , LAG-3 + PD-1 + , and TIGIT + PD-1 + cells among total donor CD8 + T cells, the progeny cells derived from the MILs and splenocytes generally expressed comparable protein levels of transcription factors, inhibitory receptors, and effector cytokines ( Fig. 4, B to D ).

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