The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer.

Also, the impact of tumor malignancy on the SOX9 gene expression level in tumor tissue was considerable and nearly significant ( P = 0.051) ( Table 7 ). 4 Discussion Despite recent improvements regarding primary bone tumor diagnosis and therapeutic strategies, nonspecific symptoms beside late patient referring and early detection failing are still prominent drawbacks causing cancer-induced morbidity and mortality [2] , [25] .

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