Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation.

Notably, day-21 titers of infectious virus and viral genome loads were lower in GvH-HCT recipients infected with immune evasion gene deletion mutant ΔvRAP (group B2) compared to recipients infected with vRAP-expressing WT virus (group B1), although the difference was less pronounced and did not reach statistical significance in liver and salivary glands ( Figure 2B ).

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