Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression.

Mol Brain · 2020 · PMC7296711 · PMID 32546197

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did not reach statistical significancep > 0.22not close (p > 0.1)

5 min post-HFS, Tukey’s p = 0.0004) and ketamine ( p = 0.0009) treated WKYs, and differences in potentiation between the two treatments did not reach statistical significance at any time point (Sidak’s p > 0.22, n.s.) (Fig. 3 e, f).

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