Consistent with reports that macrophages are key players in the pathogenesis of DKD [ 23 ], diabetic kidneys in this model showed a trend towards an increase in the macrophage cell surface marker F4/80.
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Semicarbazide-sensitive amine oxidase inhibition ameliorates albuminuria and glomerulosclerosis but does not improve tubulointerstitial fibrosis in diabetic nephropathy.
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