Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies.

Mol Psychiatry · 2020 · PMC7303008 · PMID 30374191

Europe PMC DOI

hedged sentence

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significanceP = 0.076so close (0.05 < p ≤ 0.1)

The change from baseline to EOT in MADRS-10 numerically favored BUP/SAM 2 mg/2 mg versus placebo, but did not reach statistical significance (LSMD: –1.7; P = 0.076; 95% CI: –3.6 to 0.2) (Fig. 2b ).

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